St. Joseph Cathedral is one of the most spiritual churches in Buffalo. The church was established by Buffalo's first bishop, John Timon, in 1847. The church is renowned as a historical and architectural treasure that draws faithful visitors worldwide. Their prayer and worship are the most visible places that are magnificent symbols of spirituality. The church is home to over 25 special events each year, including the Red Mass, the annual Respect for Life Mass, and the Chrism Mass. The church is an indispensable treasure that symbolizes its glorious history and provides hope for future generations. The church presents special programs, liturgies, and other opportunities for prayer, learning, and reflection. St. Joseph Cathedral invites you to explore and prayerfully offer Jesus's work at this point in your spiritual journey.

Trinity Episcopal Church is a well-established church in Buffalo. The Church was founded in 1836. The Church is a warm, dynamic community that gathers around the holy table to feed each other’s souls. The church building is an artistic, sacred space for Buffalo, home to a progressive Christian community of radical welcome. Trinity Episcopal Church is an inclusive invitation to people at all points along their spiritual journeys and from all places in society, even those on society’s margins. They have shone with a vision of the future of the Church. Trinity Episcopal Church regular Sunday worship opportunities to which they add special events from time to time. They are welcome to join and participate in any of the services held at Trinity. Trinity Church also has many events and service projects providing members of the community with other opportunities to connect.

Saint Louis Roman Catholic Church is the oldest parish in Buffalo, New York. The Church was the first Catholic Church built in Buffalo and holds the title of "Mother Church of the Roman Catholic Diocese of Buffalo. The Church is a vibrant faith community rooted in the sacramental life of the Catholic Church. The Church was established in 1829. They celebrate their rich history and invite everyone to join their growing family as they continue to serve God's people. Saint Louis Roman Catholic Church is a renowned architectural gem, and the true beauty of St. Louis Church lies in the people who make up their community. Their parish staff, volunteers, and lay leadership are deeply committed to ensuring their parish remains strong and viable. Saint Louis Roman Catholic Church parishioners worshipped here for nearly two centuries.